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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA1 All Species: 27.58
Human Site: T1242 Identified Species: 55.15
UniProt: O95477 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95477 NP_005493.2 2261 254286 T1242 S S Y G I S E T T L E E I F L
Chimpanzee Pan troglodytes XP_001138040 2261 254230 T1242 S S Y G I S E T T L E E I F L
Rhesus Macaque Macaca mulatta XP_001106713 1081 120445 Q180 H V K A E M E Q M A L D V G L
Dog Lupus familis XP_538773 2261 253895 T1242 S S Y G I S E T T L E E I F L
Cat Felis silvestris
Mouse Mus musculus P41233 2261 253955 T1242 S S Y G I S E T T L E E I F L
Rat Rattus norvegicus Q7TNJ2 2170 237702 L1208 E N G E L A K L V L D P Q A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 T1246 S S Y G I S E T T L E E I F L
Chicken Gallus gallus NP_989476 2260 254054 T1242 S S Y G I S E T T L E E I F L
Frog Xenopus laevis NP_001089022 2363 267334 T1335 S S F G I S D T P L E E I F L
Zebra Danio Brachydanio rerio XP_683123 2330 265308 S1317 G L S S F G I S D T S L E E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 R804 H Y V K E A E R G E M H G Q Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 A982 C R D R K T V A F Q F I I P A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 47 94.9 N.A. 95 50.8 N.A. 89.1 85.4 49.8 51.1 N.A. N.A. N.A. 24.9 N.A.
Protein Similarity: 100 99.7 47.5 97.6 N.A. 97.3 67.4 N.A. 94.6 92.6 66.8 67.8 N.A. N.A. N.A. 43 N.A.
P-Site Identity: 100 100 13.3 100 N.A. 100 6.6 N.A. 100 100 80 0 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 26.6 100 N.A. 100 40 N.A. 100 100 93.3 13.3 N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 17 0 9 0 9 0 0 0 9 9 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 9 0 9 0 9 9 0 0 0 % D
% Glu: 9 0 0 9 17 0 67 0 0 9 59 59 9 9 0 % E
% Phe: 0 0 9 0 9 0 0 0 9 0 9 0 0 59 0 % F
% Gly: 9 0 9 59 0 9 0 0 9 0 0 0 9 9 0 % G
% His: 17 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 0 0 0 0 59 0 9 0 0 0 0 9 67 0 9 % I
% Lys: 0 0 9 9 9 0 9 0 0 0 0 0 0 0 0 % K
% Leu: 0 9 0 0 9 0 0 9 0 67 9 9 0 0 67 % L
% Met: 0 0 0 0 0 9 0 0 9 0 9 0 0 0 0 % M
% Asn: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 9 0 0 9 0 9 9 % P
% Gln: 0 0 0 0 0 0 0 9 0 9 0 0 9 9 9 % Q
% Arg: 0 9 0 9 0 0 0 9 0 0 0 0 0 0 0 % R
% Ser: 59 59 9 9 0 59 0 9 0 0 9 0 0 0 0 % S
% Thr: 0 0 0 0 0 9 0 59 50 9 0 0 0 0 0 % T
% Val: 0 9 9 0 0 0 9 0 9 0 0 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 50 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _